It was found that a variety of plagues were prevalent in Shanghai at the end of the Qing Dynasty and the beginning of the Republic of China, by analysing and synthesising the epidemic situation, the causes of the epidemic, the social impact, and prevention and control measures. These plagues led to serious social harm and economic losses. Their causes were believed closely related to some factors, such as urban environment, population flow, and climate changes. Their prevention appeared to be applicable and effective. The Shanghai concession and Chinese authorities organised society to fight against plagues and stabilise the social order. Charity organisations of the local communities were also involved in social support. It was found that more can be done in studies on interdisciplinary synthesis, comparative study of epidemic prevention measures of managers, and of traditional Chinese medicine prevention and treatment