Malaria is one of the infectious diseases that is a problem for public health in the world, most vulnerable to befalling ages such as children and the elderly which usually occurs in the rainy season. The purpose of this study was to determine the effect of health promotion interventions on the knowledge, attitudes, and action of malaria patients in Bengkulu and Lubuklinggau City. This study was using the Quasi Experiment method. The population of this study was 519 patients at the Lingkar Timur Health Center and 423 patients at the Perumnas Lubuk Linggau Health Center. There is an increase in knowledge, attitudes, and actions before and after the intervention is given. There is an effect of health promotion interventions using pocketbooks on knowledge, attitudes, and actions in malaria patients. There is an effect of health promotion interventions using pocketbooks on knowledge, attitudes, and actions in malaria patients. Suggestions are expected for other researchers to develop different research designs and for policymakers to develop policies related to malaria prevention.