Abstract : Jaundice is a frequent symptom in the neonatal period. It is caused by the deposition of bilirubin pigment in the skin and tissues. Its seriousness lies in its potential evolution towards neurotoxicity. The aim of this work is to analyze the clinical, etiological, therapeutic and evolutionary characteristics of neonatal jaundice at our center. This is a retrospective descriptive study, carried out over a period of 2 years (January 2018 to December 2019) at the national reference center for neonatology at the Rabat Children's Hospital. It targeted all newborns hospitalized for neonatal jaundice at the department. 526 cases of neonatal jaundice were recorded among 5896 newborns hospitalized during this period, representing 8.9% of admissions. Male predominance was noted, with a percentage of 57.4%. 74.3% of cases were eutrophic, 8.2% macrosomic and 17.5% hypotrophic. The notion of peri- and/or neonatal suffering was noted in 3.2% of cases. Etiologies were dominated by ABO incompatibility in 39.4% of cases, followed by neonatal infection in 27.6%, physiological jaundice in 16%, and finally rhesus incompatibility in 11.4%. Phototherapy combined with etiological treatment was the mainstay of therapeutic management. Mortality occurred in 2.3% of cases, with a favorable outcome in 97.7%. Despite the favorable evolution of jaundice in the majority of newborns, it remains a frequent symptom at risk of serious complications.