The main objective of our retrospective descriptive study was to describe antibiotic prescribing practices among adults hospitalized at the Sheikh Zaid International University Hospital (HUICZ) in Rabat. During the first day of each month of the year 2020, the use of antibiotics was analyzed according to the parameters researched and recorded in an exploitation form. Out of a total of 307 patients hospitalized during the same period, 109 received antibiotic therapy, but only 82 medical records met our data processing criteria. 35.5% of adult hospitalized patients received antibiotic therapy. The majority were between 61 and 80 years of age. The male gender dominated this age group. 62.2% received antibiotic prophylaxis, mainly in the digestive surgery department. Amoxicillin-clavulanic acid and ciprofloxacin were the most prescribed. The compliance rate for the duration of antibiotic prophylaxis was 47%. In addition, curative antibiotic therapy was requested in 37.8% of cases, particularly in the intensive care unit, and was mainly motivated by urinary tract infections. These infections concerned the community germ Escherichia coli and three nosocomial germs: Acinetobacter baumanii, Enterococcus faecium and Staphylococcus aureus. Ceftriaxone and ciprofloxacin were the most prescribed. Antibiotic treatment was effective in 64.5% of patients. Generally, the beta-lactam family predominated, injectable dosage forms were the most widely administered and monotherapy was the most requested. Curative antibiotic therapy was more expensive than antibiotic prophylaxis. Generic antibiotics were prescribed more than originator drugs.