To assess stress among healthcare professionals caused by the Covid19 pandemic in a Moroccan hospital. An evaluative quantitative study conducted during the first year of the pandemic's onset in Morocco (March 2020-March 2021). A self-administered questionnaire was used to assess stress among professionals. Out of 365 hospital professionals participating in the study, the average stress score was 50.8, indicating a high level of stress. The profile most affected was that of nurses, followed by health technicians and doctors. The main cause of this high stress level was the discomfort caused by the equipment, followed by the burden of patient management. Also we raised that there is a significant association between the level of severe stress and the risk factors of this stress which are gender, marital status, seniority at work, practice in the first rank, professional profile, quarantine, except for the factor of stigmatization does not constitute a factor favoring stress in our participants. This study was able to demonstrate that healthcare professionals were subjected to significant stress caused by the COVID-19 pandemic, and more specifically those working in the front line. However, demographic and social factors had an impact on the stress levels of the professionals approved by the literature review.