Chinese Journal of Medical History / Zhong Hua Yi Shi Za Zhi

[This article belongs to Volume - 53, Issue - 05]

Abstract : Schinus terebinthifolius Raddi (S.T), commonly known as the Brazilian pepper tree, is an Anacardiaceae family evergreen shrub. The fruits of S. terebinthifolius, renowned for their aromatic flavor, have garnered interest due to their potential medicinal properties and function in the prevention and treatment of diseases. This study aims to assess the acute toxicity (14 days) of an ethanolic extract of S. terebinthifolius Raddi fruit through oral administration (gavage) in female Wistar rats. The ethanolic extract of the berries was orally administered via gavage at various doses of 2.5, 5, 25, 50, and 250 mg/kg (n = 5/group). In the acute toxicity test, the S. terebinthifolius extract did not exhibit any toxic effects or mortality in Wistar rats. Furthermore, the administration of the extract did not induce significant changes in body weight, rectal temperature, or water and food intake. However, biochemical analyses indicated significant changes in ASAT and ALAT levels, as well as lipid profiles. Behavioral evaluations indicated noticeable changes in locomotor activity, with rats given the extract showing increased signs of anxiety. Histopathological examinations of rats treated with the ethanolic extract demonstrated the absence of toxic effects on the liver and kidneys. The acute administration of the ethanolic extract of Schinus terebinthifolius Raddi fruit did not elicit any toxic effects in Wistar rats.